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BIG BRAINS
SINCE 1993
International Education
35 Years of Practical Research & Development Programme.
A HI-TECH FUTURISTIC BABY LEARNING
BRAIN IS BIG NOW
Our Role is Important in this WORLD.
WOMB LEARNING
RESEARCHES
Welcome to Womb Learning Research, your source for science-based insights on prenatal brain development and fetal learning. Explore research on how sound, emotion, and sensory experiences in the womb shape neural connections, memory formation, and early intelligence. Discover evidence-backed findings on how the pregnancy environment influences lifelong cognitive and emotional development. All images shown here are A.I. Images.
Fetal habituation to vibroacoustic stimulation in relation to fetal states and fetal heart rate parameters
Fetal habituation to vibroacoustic stimulation in relation to fetal states and fetal heart rate parameters
The responses to repeated vibroacoustic stimulation in a fetus with trisomy 18
Observation of fetal heart rate (FHR) and fetal movement (FM) responses to vibroacoustic stimulation (VAS) has been shown to be effective in identifying the acidotic fetus and predicting a reassuring biophysical profile. Habituation of FM and FHR responses to repeated VAS might be a measure of fetal well-being and the integrity of the fetal central nervous system. The study presents a case of a fetus with trisomy 18 that failed to respond to repeated VAS at 31 and 33 weeks of gestational age (GA).
Fetal habituation to vibroacoustic stimulation in uncomplicated postterm pregnancies
Objectives: Testing of fetal habituation to repeated vibroacoustic stimulation might give additional information concerning the fetal condition and central nervous system (CNS) functioning in postterm pregnancies. This study is designed to investigate whether healthy postterm fetuses are able to habituate and if so, if the habituation pattern of postterm fetuses differs from that of term fetuses. Study design: Twenty women with an uncomplicated pregnancy beyond 41 weeks
Fetal learning and memory.
We used fetal habituation to repeated vibroacoustic stimulation to assess fetal memory. After the initial stimulus, we assessed the fetuses 10 min later and again after 24 h. 16 of 19 fetuses habituated rapidly to the stimuli at 10 min (p=0.004) and 24 h (p=0.042) after the initial test. We conclude, therefore, that fetuses are able to learn: they have a short-term memory of at least 10 min, and a long-term memory of at least 24 h.
Fetal Movement in Response to Vibroacoustic Stimulation
etal movement in response to vibroacoustic stimulation (VAST) depends on functional maturation of the fetal central nervous system and related to changes in fetal behavior. Researchers have associated the presence of fetal movement with fetal well-being. Use of the maternal perception of sound-provoked fetal movement as a test for predicting fetal health is questionable and may suggest further research. All studies show that there is a clear association between this test and favorable neonatal outcomes. This test is inexpensive and easily obtainable. However, because the test has not been studied on large numbers of patients and maternal reporting at times is biased, its adaptation for clinical use should cautiously wait for clear theoretical advantages.
An encephalocele compared to responses of normal fetuses
Prenatal Stress and the Developing Brain: Postnatal Environments Promoting Resilience.
Heightened maternal stress during pregnancy is associated with atypical brain development and an elevated risk for psychopathology in offspring. Supportive environments during early postnatal life may promote brain development and reverse atypical developmental trajectories induced by prenatal stress. We reviewed studies focused on the role of key early environmental factors in moderating associations between prenatal stress exposure and infant brain and neurocognitive outcomes. Specifically, we focused on the associations between parental caregiving quality, environmental enrichment, social support, and socioeconomic status with infant brain and neurocognitive outcomes.
Developmental programming of early brain and behaviour development and mental health.
The Developmental Origins of Health and Disease (DOHaD) hypothesis studies the short- and long-term consequences of the conditions of the developmental environment for phenotypic variations in health and disease. Central to this hypothesis is the idea of interdependence of developmental influences, genes, and environment. Developmental programming effects are mediated by alterations in fundamental life functions, and the most enduring effects seem to occur if the main regulatory instances of the organ – the (epi)genome and the brain – are affected. Some new insights in the role of chromatin, in cellular development and differentiation, and neural plasticity from the field of epigenetics are introduced, followed by a section on epigenetics and brain development. It is proposed to extend the DOHaD hypothesis into the ‘Developmental Origins of Behaviour, Health, and Disease’ (DOBHaD) concept. Pregnancy and the early postnatal period are times of both great opportunity and considerable risk, and their influence can extend over a lifetime. The DOBHaD hypothesis opens fundamental new perspectives on preventing diseases and disorders.
Maternal factors during pregnancy influencing maternal, fetal, and childhood outcomes.
Enhancing pregnancy health is known to improve the mother’s and offspring’s life-long well-being. The maternal environment, encompassing genetic factors, impacts of social determinants, the nutritional/metabolic milieu, and infections and inflammation, have immediate consequences for the in utero development of the fetus and long-term programming into childhood and adulthood. Moreover, adverse pregnancy outcomes such as preterm birth or preeclampsia, often attributed to the maternal environmental factors listed above, have been associated with poor maternal cardiometabolic health after pregnancy. In this BMC Medicine article collection, we explore a broad spectrum of maternal characteristics across pregnancy and postnatal phenotypes, anticipating substantial cross-fertilization of new understanding and shared mechanisms around diverse outcomes.
Maternal Factors Associated with Fetal Growth and Birthweight
Maternal nutritional and metabolic factors influence the developmental environment of the fetus. Virtually any nutritional factor in the maternal blood has to pass the placental membranes to reach the fetal blood. Placental weight is a commonly used measure to summarize placental growth and function. Placental weight is an independent determinant of fetal growth and birthweight and modifies the associations between maternal metabolic factors and fetal growth. We hypothesized that maternal factors known to be related to fetal growth, newborn size and body composition are determinants of placental weight and that effects of maternal metabolic factors on placental weight differ between the genders.
Maternal Nutrition and Fetal Development.
Nutrition is the major intrauterine environmental factor that alters expression of the fetal genome and may have lifelong consequences. This phenomenon, termed “fetal programming,” has led to the recent theory of “fetal origins of adult disease.” Namely, alterations in fetal nutrition and endocrine status may result in developmental adaptations that permanently change the structure, physiology, and metabolism of the offspring, thereby predisposing individuals to metabolic, endocrine, and cardiovascular diseases in adult life. Animal studies show that both maternal undernutrition and overnutrition reduce placental-fetal blood flows and stunt fetal growth. Impaired placental syntheses of nitric oxide (a major vasodilator and angiogenesis factor) and polyamines (key regulators of DNA and protein synthesis) .....
Ayurvedic approach to Embryogenesis: Exploring Fetal Development.
Embryology in Ayurveda is the study of embryonic and fetal development using Ayurvedic principles. Ayurveda describes the conception process, fetal development, and the effect of Doshas (biological energies) on the fetus's growth and health. Ayurvedic embryology emphasizes the mother's health and well-being during pregnancy, as well as the effect of the father's Doshas on the child's genetic makeup. It also includes prenatal care guidelines, such as diet, lifestyle, and herbal remedies, to help the fetus develop normally. Aims: This review applies Ayurvedic concepts of Grabhasharir to embryology, analyzing the genesis of progeny using modern scientific knowledge. Materials and Methods: Brihattrayee along with other relevant literature were reviewed to identify the hidden core of embryology described in chapters about Garbhasharir. Results: The Ayurvedic essence outlines two types of processes in progeny genesis: dependent and independent, with dependent processes modifying and independent processes unaffected by parental efforts. Conclusion: Even though the embryology concepts outlined in Ayurveda extend back millennia, they are still relevant in today's scientific world when properly interpreted.
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